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Whole-brain projection patterns of single neurons in the mouse hippocampus revealed

manhattantribune.com by manhattantribune.com
1 February 2024
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Whole-brain projection patterns of single neurons in the mouse hippocampus revealed
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Coronal sections of the longitudinal axis of the hippocampus. Credit: CEBSIT Digital Brain

A study published in Science reports a comprehensive single-neuron projectome database comprising more than 10,000 mouse hippocampal neurons, revealing the spatial connectivity patterns of mouse hippocampal neurons at the mesoscopic level.

The study was carried out by teams from the Center of Excellence in Brain Sciences and Intelligence Technologies (CEBSIT), the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), the HUST Institute -Suzhou for Brainsmatics, from Hainan University, Kunming Institute of Zoology of CAS, Lingang Laboratory and Shanghai Center for Brain Science and Brain-Inspired Technology.

The hippocampus constitutes a brain region essential for learning and memory as well as various brain functions such as spatial cognition and emotion processing. It is one of the most studied brain regions. Hippocampal neurons project widely to brain-wide targets; it is therefore essential to study the projection patterns of hippocampal neurons at the single-neuron level.

The study reconstructed the whole-brain axonal morphology of more than 10,000 neurons in the mouse hippocampus at single-cell resolution, with neuronal cell bodies spanning all subregions and multiple locations along different axes of the hippocampus. , making it the most comprehensive single-neuron projectome database in the world. the world.

The study took an innovative approach to categorize axonal trajectories with machine learning algorithms, thereby enabling more efficient analysis of morphological similarities between 341 projection patterns for mouse hippocampal neurons and ultimately identifying 43 projectome cell types distinct. It also incorporated the spatial transcriptome of mouse CA1 areas.

Based on these analyses, the study was able to elucidate the axonal projection pathways of hippocampal neurons along the anteroposterior axis and reveal new projection patterns of hippocampal neurons. He also described the correspondence between the soma locations of hippocampal neurons and projection targets, and revealed the basic organizing principles of bilateral projections.

Furthermore, correlation analysis of projectome cell types and spatial transcriptome data identified spatial correspondence between various genes and projectome subtypes, thereby providing potential molecular and circuit targets for functions of the projectome. seahorse.

Taken together, this study provides a structural basis for future studies of hippocampal functions and deciphers potential correspondences between their soma locations, gene expression, and circuit functions.

The Hippocampal Single Neuron Projectome Database, as well as the Hippocampal Long Axis and Spatial Transcriptome Database, are now publicly available through the CEBSIT Digital Brain Portal.

To facilitate wider use of the databases, a team from the CEBSIT Computing and Data Center developed a website to integrate data visualization, user interface, online analysis and data uploading.

More information:
Shou Qiu et al, Whole-brain spatial organization of single-neuron hippocampal projectomes, Science (2024). DOI: 10.1126/science.adj9198. www.science.org/doi/10.1126/science.adj9198

Provided by the Chinese Academy of Sciences

Quote: Whole-brain projection models of single neurons in the mouse hippocampus revealed (February 1, 2024) retrieved February 1, 2024 from

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Tags: hippocampusMouseneuronspatternsprojectionrevealedsingleWholebrain
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