Credit: UNSPLASH / CC0 public domain
Researchers at the Memorial Sloan Kettering Cancer Center and the University of California in Los Angeles, have identified that co -corbidities in the forties are associated with an increased risk of developing cancer and mortality related to cancer, with associations varying according to the type of cancer. Chronic conditions were linked to higher risk of cancer, offering information that can shed light on prevention efforts.
Cross -communication, in which the diagnosis of a chronic condition accelerates the risk of a different subsequent disease, receives increasing attention. Preclinical studies have shown that heart events such as heart failure and myocardial infarction can stimulate tumor growth and metastases in mouse of intestinal and breast cancer mice.
Clinical studies show that individuals diagnosed with heart failure or myocardial infarction face an increased risk of developing cancer compared to individuals without these conditions.
Screening remains a concern, as individuals diagnosed with heart conditions may undergo more frequent medical assessments, leading to previous detection of cancer. Larger assessments in a system of systematically classified comorbidities are necessary to confirm associations.
In the study, “comorbidity in quarantine and the results of cancer”, published in Jama Network OpenThe researchers carried out a secondary analysis of the prospective testing test of prostate, lung, colorectal and ovary (PLCO) to study how the comorbidities of the quarantine affect the risk and mortality of future cancer.
A cohort of 128,999 adults aged 55 to 74 was registered between 1993 and 2001 in 10 PLCO screening centers across the United States. The participants declared stories of 12 comorbid conditions, classified into five categories guided by the taxonomy of the organization of global health: cardiovascular, respiratory, gastrointestinal, liver and metabolic conditions.
After 20 -year -old median follow -up, only the respiratory stories (HR 1.07, 95% CI 1.02–1.12) and cardiovascular (HR 1.02, 95% CI 1.00 to 1.05) were associated with a statistically significant increase in the overall incidence of cancer. Metabolic, gastrointestinal and liver conditions have not raised the risk of panicking, although everyone is strongly linked, positively or negatively, to several specific types of cancer. Each comorbid condition was associated with an increased risk of at least one type of cancer.
The liver conditions had the strongest association with the future liver cancer (HR, 5.57; 95%CI, 4.03–7.71). Metabolic conditions were linked to a higher risk of nine types of cancer and a lower risk of four types, including pulmonary and prostate cancers.
Respiratory conditions (HR, 1.19; 95%CI, 1.11–1.28), cardiovascular conditions (HR, 1.08; 95%CI, 1.04–1.13), and metabolic conditions (HR, 1.09; 95%CI, 1.05–1.14) were associated with specific mortality.
The results indicate that the comorbidities of the quarantine influence the development of cancer and the risk of mortality. Public health strategies focused on early detection and chronic conditions management can help improve prevention and cancer results. The formal integration of comorbidity screening in routine cancer risk assessments could support more personalized cancer prevention programs.
More information:
Jessica A. Lavery et al, comorbidity in quarantine and the results of cancer, Jama Network Open (2025). DOI: 10.1001 / JamanetWorkopen.2025.3469
Siran M. Koroukian et al, get closer to personalized cancer prevention strategies by assessing comorbidity and multimorbidity, Jama Network Open (2025). DOI: 10.1001 / JamanetWorkopen.2025.3476
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Quote: The long -term study links chronic conditions in living environment to higher risk and mortality (2025, April 28) recovered on April 28, 2025
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