New mapping method illuminates drug sites on proteins
A protein with unknown binding sites (left), versus a protein with high-resolution binding site mapping (right). Credit: Scripps Research Identifying ...
Tag: drug
Experimental drug that alters gut microbiome shows promise for prolonged COVID relief
Proportion of PACS symptom reduction within six months. Credit: Lancet infectious diseases (2023). DOI: 10.1016/S1473-3099(23)00685-0 A randomized controlled trial conducted ...
A new era in drug development
Graphical summary of cyclic oral peptides. Credit: Christian Heinis/EPFL For decades, a significant number of proteins, essential for the treatment ...
Study on the genetics of pericarditis improves understanding of newly approved drug treatment
Rosa B. Thorolfsdottir, scientist at deCODE Genetics in Iceland and first author of the paper. Credit: deCODE genetics Sequence variants ...
Gut microbes may determine how patients respond to a drug that delays the onset of type 1 diabetes
Teplizumab delays type 1 diabetes (T1D) in at-risk people in the TN10 trial, but participants respond differently to the treatment. ...
Research reveals molecular origins of how a key drug target works
By examining each individual component of the β2 adrenergic receptor and seeing how they contribute to the overall function of ...
Massive drug search uncovers infinitesimal molecule that kills cancers while sparing immune cells
N6F11 suppresses human PDAC growth. (A) PANC1 cells were pretreated with DMSO or N6F11 (5 µM) for 12 hours. (B) ...
Discovery of a drug candidate to potentially fight ER-positive breast cancer
Credit: Cellular chemical biology (2023). DOI: 10.1016/j.chambiol.2023.07.005 An international team of researchers, led by Pfizer in collaboration with Monash University ...
New neuromuscular model promises to revolutionize high-throughput drug screening studies
A human self-organized 2D neuromuscular junction model. Immunofluorescence analysis of the whole dish shows muscle cells (magenta) organized into bundles ...
Significant benefit seen in phase III trial of experimental kidney disease drug
Credit: Pixabay/CC0 Public domain In a clinical trial of patients with chronic kidney disease, an investigational drug significantly reduced albuminuria ...
