Credit: TIMA MIROSHNICHENKO DE PEXELS
Researchers have discovered that targeting an enzyme called PGM3 can help stop glioblastoma growth, the most dangerous brain tumor type. The results of the study are published online in the journal Scientific advances.
This enzyme plays a vital role in the summary path of hexosamine, which is involved in the protein and lipid glycosylation processes that allow tumors to develop quickly. Lipid glycosylation is a process where sugar molecules attach to fats (lipids) in the body.
Researchers from the Ohio State University Understanding Cancer Center – Arthur G. James and Richard J. Solove Research Institute believe that targeting of PGM3 can reduce tumor growth and eliminate glioblastoma cells.
“This research is important because it has found a new target called PGM3. The blocking of the enzyme PGM3 can break the link between sugar and the creation of fats in cells, which helps tumors to grow.
Glioblastoma is a fast -growing brain tumor that develops from glial cells in the brain. It is estimated that 15,000 people each year are diagnosed with this fatal cerebral tumor, according to the glioblastome foundation.
The study highlights a new promising approach to fight against glioblastoma, giving hope for future progress in cancer treatment, said Guo, who is also a professor of urban research and Sheyer Sheyer of Cancer with the OSUCC – James Translational Therapeutics Program and professor of radiation department in Ohio State University College.
“Glioblastoma is the tumor of the most deadly primary brain, with median survival of only 12 to 16 months after the diagnosis despite in-depth treatments,” said Hudi SU, Ph.D., the first author of the article and researcher of the Department of Radiation and the Center of Cancer Metabolism in OSUCCC-James. “New molecular targets for glioblastoma are urgently necessary.”
The research team included scientists from France, as well as the University of California-Los Angeles, the University of California-Irvine and the University of Louisville.
More information:
HUDI SU et al, PGM3 targeting, abolishes the regulation of feedback from activation of activation of activation and synthesis to effectively remove tumor growth from the brain, Scientific advances (2025). DOI: 10.1126 / SCIADV.ADQ0334. www.science.org/doi/10.1126/sciadv.adq0334
Supplied by Ohio State University Medical Center
Quote: Research identifies the key enzymatic target to fight against mortal brain cancers (2025, April 18) recovered on April 19, 2025 from
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