New generation biobatterie shrinks the tumor, paving for cancer treatments without medication

It has been shown that a pioneer biobatterie reduces tumor growth in the body and could maintain the key to a new treatment of without medication immunotherapy in cancer patients.

La Percée, a global collaboration between the distinguished professor Gordon Wallace and Professor Caiyun Wang of the Institute of Intelligent Polymer Research (IPRI) of the University of Wollongong (UOW) and researchers from the University of Jilin in China, is described in a new article published in Scientific advances.

Biobattions have the same basic parts as regular batteries – two electrodes (anode and cathode), a separator and an electrolyte – but use biological processes to create electricity. The document examines how biobatteries can be used to target tumors and trigger an immunotherapy response located in the body.

When the battery is used, tiny particles called electrons are released from an electrode (anode) and move to the other (the cathode), where they are consumed. These movements are accompanied by chemical reactions which exploit the immune response of the body.

When the biobattery was placed around subcutaneous tumor sites (tumors that occur between the skin and the muscle), the treatment has reduced the size of the tumor by more than 1,000 mm³ only 4 mm³A reduction of 99.6% after 14 days.

Professor Wallace said the research was based on the team’s previous work in biobattions and results were extremely promising for cancer treatment.

“The concept of biobatterie was designed several years ago when we examined the conventional implantable batteries and we thought:” What waste of space and why are they not designed to interact directly with the tissues? “” He said.

“In this research, the by -products of the battery discharge – zinc and manganese ions – create a chemical environment that inhibits tumor growth.

“If we are intelligent with a choice of electrode, biobattions can be more effective in the treatment of medical conditions, in particular the mobilization of the body’s immune response and the narrowing of tumors.”

Although the battery current can inhibit tumor growth, when combined with the targeted release of metallic ions, it has a dramatic impact, stimulating immunotherapy, a powerful and effective tool for treating cancer.

Professor Wang, a professor professor in IPRI, said that the release of zinc and manganese ions helped the body’s immune system to find and destroy cancer cells.

“We can place the battery directly on the tumor site so that it continually releases metallic ions where cancer is. This helps kill cancer cells while helping the patient’s immune system to recognize and attack the tumor,” she said.

Professor Associate Jia Xiaoteng of Jilin University said that research could provide a new path to treat tumors without using severe drugs, potentially reducing side effects and improving the patient’s quality of life.

“This work demonstrates a powerful electrochemical tool for immunotherapy against cancer without medication, which can open an avenue for sustained and targeted delivery of substances that activate the immune system,” he said.

Professor Wallace said that this research caliber was made possible by the collaboration between the UOW and the Jilin University and the next step is to ensure that biobatterie is making its way around the world.

“We are going to rely on our vast clinical network to create preclinical and clinical research. We are committed to guarantee that this device is used and capable of helping people as soon as possible,” he said.

“The major world challenges require integrated global research teams to resolve them if we want to progress.”