Comparison of two populations of stem cells from wisdom teeth shows notable differences in the differentiation potential of the cells.
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A new American study reveals the most complete genetic map of oral stem cells to date, paving the way for targeted regenerative medicine and therapies for bone growth.
The research team from the ADA Forsyth Institute and the University of North Carolina (USA) used single-cell transcriptomic analysis to map stem cells from the dental pulp and periodontal ligament of extracted wisdom teeth . The results published in the Journal of Dental Research show “ remarkable differences between them “. Indeed, the single groups of the periodontal ligament resembled fibroblasts (cells that can differentiate to form connective tissue), whereas the single groups of the dental pulp showed a higher differentiation potential, to convert into osteoblasts. These are cells that can repair existing bones or form new ones.
Stem cells to repair dental tissue
By finding that the genetic makeup of dental pulp groups predisposed them to differentiate into osteoblasts, the researchers hope to exploit stem cell therapy for tooth regeneration. “ We could potentially select a stem cell based on its distinct properties to create targeted regenerative therapies for dental tissue repair and other regenerative therapies », They write in their article.
